Cellular Neurobiology Lab | Fondazione Santa Lucia

Cellular Neurobiology Lab

Areas of Investigation 

The studies carried out in the Laboratory of Cellular Neurobiology have focused on the pathophysiological role of purinergic receptors in neuro-degenerative and neuro-inflammatory diseases of the nervous system such as, in particular, multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Through pharmacological analysis, biochemical, molecular and cell-morphology, are investigated the methods of activation and inhibition of purinergic receptors, as well as their biological effects. The studies are designed to prevent diseases of the nervous system and slow their progression.

 

Purinergic receptors: Function and Mechanism of Action

The research activity of the Laboratory focuses in particular on the purinergic P2X and P2Y receptor types, which are membrane receptors activated by purine and pyrimidine molecules. These are exemplified by Adenosine Triphosphate (ATP), which is the universal molecule for energy exchange within each cell. In addition, ATP is localized abundantly in the extracellular spaces of tissues and organs of the human body, especially after cell stimulation or cell damage, so becoming a molecule also important for exchange of information between cells. In particular, the Laboratory is studying the function and mechanism of action of these receptors in the cells of the nervous system, namely neurons and glial cells (oligodendrocytes, astrocytes and microglia).

Acquired Patents 
  • Use of selected modulators of P2 purinoceptors for the prevention of damage and mortality caused by global cerebral ischemia and ischemia reperfusion. PCT / EP99 / 08999
  • Use of agonists or antagonists of P2 purinoceptors for the prevention of glutamate-evoked cytotoxicity. PCT / EP96 / 03254
Collaborations 
  • Axxam SpA, Openzone - Bresso, Milan (Italy)
  • Department of Biology, Tor Vergata University of Rome, Rome (Italy)
  • Institute of Cell Biology and Neurobiology, National Research Council (CNR), Rome (Italy)
  • National Institute of Health, Rome (Italy)
Ongoing Research Projects 
  • New insights on the role of purinergic P2Y12 receptor in Multiple Sclerosis
  • Mammals
  • Path-for-ALS
  • MIUR-CNR, Flagship Project Nanomax B81J13000310005

Laboratory of Cellular Neurobiology

Fondazione Santa Lucia Irccs

Via del Fosso di Fiorano, 64 00143 Rome

European Centre for Brain Research (CERC) – Floor 1 – Room 111