Neuropsychiatry Lab | Fondazione Santa Lucia

Neuropsychiatry Lab

Areas of Investigation 

The Laboratory investigates the clinical phenomenology and biological bases of neuropsychiatric diseases. The areas range from psychopathology to neuropsychology, from molecular and cellular biology to neuroimaging. The approach is multidimensional, using different survey methods and different assessment tools. Data collection and data analysis are conducted by a multidisciplinary team consisting of psychologists, biologists, physicians and physicists.

 

Clinical Activity, Biomarkers and Neuroimaging

The Laboratory of Neuropsychiatry studies the biological and genetic markers over the activity of early diagnosis of neurodegenerative diseases (dementia and movement disorders), cerebrovascular (stroke) and psychiatric (schizophrenia, bipolar disorder, depressive disorder, obsessive compulsive disorder). Such markers are also used for the prediction of the clinical course of the disease.

The further study of the individual's cognitive function is accomplished with the use of standardized neuropsychological tests, and neuropsychiatric symptoms can be analyzed through psycho-diagnostic and psychometric scales. The results allow to characterize the cognitive and psychopathological profiles of patients with neurological and psychiatric diseases. The profiles are then correlated to any structural, functional and metabolic brain alterations, detectable by qualitative and quantitative techniques of neuroimaging. These techniques, widely used by the Laboratory, allow us to draw inferences about brain changes that underlie neurological and psychiatric diseases and their symptomatic manifestations.

 

Research Linked to the Local Network

The Laboratory works with several hospitals in Rome: Sant'Andrea Hospital (Sapienza University of Rome), Sant’Alessandro Nursing Home (Tor Vergata University of Rome), Tor Vergata University Hospital, Villa von Siebenthal, Mental Health Departments of the Public Health Services (ASL) Roma E and Roma H. Many of the stakeholders are included in research protocols and followed throughout the course of the disease. The assessment carried out for scientific purposes allows a better definition of clinical parameters useful for therapeutic purposes.

Collaborations 
  • Cognitive Neuroscience Laboratory, Department of Psychology, Bar-Ilan University, Tel Aviv (Israel)
  • Department of Clinical Neurosciences, Max-Planck-Institut für Experimentelle Medizin, Göttingen (Germany)
  • Department of Mental Health, ASL Roma E
  • Department of Mental Health, ASL Roma H
  • Department of Neuroscience and Department of Systems Medicine, Neurology Unit, Tor Vergata University Hospital, Rome (Italy)
  • Department of Neuroscience, Psychiatry and Clinical Psychology Unit, Tor Vergata University Hospital at St. Alexander Nursing Home, Rome (Italy)
  • Department of Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, Texas (United States)
  • Faculty of Medicine and Psychology, Sapienza - University of Rome
  • Laboratoire de Neurosciences Cognitives Universite de Provence, Marseille (France)
  • School of Medicine, Department of Psychiatry, Trinity College, Dublin (Ireland)
  • School of Medicine, Institut für Zelluläre Chemie, Leibniz Universität, Hannover (Germany)
Ongoing Research Projects 
  • Studio dell’epidemiologia dei disturbi comportamentali e cognitivi in soggetti con disturbi del movimento, con e senza impianto DBS, effettuato attraverso strumenti specificamente validati per tali patologie neurologiche
  • NeuConnect: Novel strategies for the treatment of schizophrenia based on genetic variation of the neural cell adhesion molecule NCAM and enzymes involved in its posttranslational modifications (ERANET Neuron)
  • Studio degli effetti comportamentali, neuropsicologici e biologici della psicoterapia psicodinamica integrata breve sul disturbo depressivo nei pazienti con Malattia di Parkinson
  • Valutazione neuropsicologica, comportamentale e neuroradiologica, prima e dopo intervento chirurgico di stenosi carotidea in pazienti asintomatici
  • Mhealth platform for Parkinson’s disease management —  PD_manager (The EU Framework Programme for Research and Innovation - HORIZON 2020)
  • Studio dei parametri infiammatori, comportamentali, cognitivi e neuroanatomici in pazienti con ictus cerebrale in fase acuta: studio osservazionale spontaneo con follow-up naturalistico in setting riabilitativo
  • Development of operational research diagnostic criteria for diagnosis of Alzheimer's disease in the preclinical/predementia phase and implementation of SOPs for imaging and CSF biomarkers in Memory Clinics. An integrated care pathway for early diagnosis and best management in the National Health Service of five Italian regions (Network Research of the IMH)
  • Valutazione multidimensionale clinica, neuropsicologica, neuroradiologica e genetica di pazienti con disturbo ossessivo-compulsivo e comparazione con soggetti di controllo
  • Valutazione longitudinale e multidimensionale clinica, neuropsicologica, neuroradiologica e genetica di pazienti all’esordio di malattia psichiatrica
  • Looking for new insight on Omega-3 fatty acids role on cognitive decline and brain dysfunctions in age-related disorders (Young Research Project of the IMH)
  • Studio con tipizzazione mirata diagnostica, psicopatologica, neuropsicologica e morfologica cerebrale di pazienti con diagnosi di schizofrenia
  • Valutazione longitudinale e multidimensionale clinica, neuropsicologica, neuroradiologica e genetica di pazienti in età evolutiva e adulti con disturbo da deficit dell’attenzione e iperattività (ADHD) e comparazione con soggetti di controllo
  • Valutazione multidimensionale neuropsicologica, comportamentale, neuroradiologica e genetica di soggetti con mild cognitive impairment, demenza d'Alzheimer e comparazione con soggetti di controllo: analisi longitudinale dei predittori di decorso clinico
  • L’anosognosia negli stadi clinici e preclinici della malattia di Alzheimer come predittore precoce di esito di malattia: impatto sulla diagnosi precoce e interventi riabilitativi

Laboratory of Neuropsychiarty

Fondazione Santa Lucia Irccs

Via Ardeatina, 354 – 00179 Rome

Building A, Floor 4, Rooms 404,405,406

Buliding B, Floor 1, Rooms 31,135,147,148,152